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UNKNOWNNCT04716023

Physiology and Structure of the Small Airways in Patients With Chronic Airflow Obstruction or COVID-19

The purpose of this research project is to study small airways physiological function in patients with chronic obstructive lung disease or COVID-19 and explore the relationship with in-vivo microanato...

Lead sponsor: Imperial College London•1 locations•View source on ClinicalTrials.gov

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Contacts

Christopher M Orton, MBBS

CONTACT

02073518029 c.orton@rbht.nhs.uk

Sponsors

Lead Sponsor

Imperial College London

Age

16 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•1. Age 16 or over
•2. Scheduled for bronchoscopy as part of clinical care or research protocol
•3. No bleeding diathesis or therapeutic anticoagulation
•4. COPD:
•* FEV1/FVC ratio \<70% or
•Asthma:
•Diagnosed by standard clinical methods
•Post-bronchodilator FEV1 ≥60% predicted or COVID-19 infection or previous COVID-19 infection (confirmed as per local guidelines)

Exclusion Criteria

•1. Unable to provide informed consent
•2. Exacerbation of obstructive airways disease or respiratory infection requiring systemic antibiotics or corticosteroids in the 6 weeks prior to enrolment unless suffering from COVID-19 infection and bronchoscopy is required for clinical reasons
•3. Contra-indications to performing lung function testing
•* Aortic aneurysm \>6cm
•* Unstable cardiovascular disease (unstable angina, myocardial infarction or pulmonary embolism \<4 weeks prior)
•* Severe aortic stenosis
•* Pneumothorax
•* Cerebral aneurysm
•* Thoracic or abdominal surgery \<4 weeks prior
•4. Contra-indications to passing oesophageal balloons
•* Oesophageal ulceration or varices
•* Sinusitis, recent nasal surgery or epistaxis

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: January 20, 2021Terms

Trial snapshot

StatusUNKNOWN

Phase—

Enrollment42

Start dateAug 2019

Last updatedJan 20, 2021

Condition

Copd COVID-19 Asthma Small Airways Disease

Locations shown

The Royal Brompton

London

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 20, 2021Data synced to Clareo: April 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions