Christopher M Orton, MBBS

CONTACT

Lead Sponsor

Imperial College London

Age

16 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. Age 16 or over
•2. Scheduled for bronchoscopy as part of clinical care or research protocol
•3. No bleeding diathesis or therapeutic anticoagulation
•4. COPD:
•* FEV1/FVC ratio \<70% or
•Asthma:
•Diagnosed by standard clinical methods
•Post-bronchodilator FEV1 ≥60% predicted or COVID-19 infection or previous COVID-19 infection (confirmed as per local guidelines)

•1. Unable to provide informed consent
•2. Exacerbation of obstructive airways disease or respiratory infection requiring systemic antibiotics or corticosteroids in the 6 weeks prior to enrolment unless suffering from COVID-19 infection and bronchoscopy is required for clinical reasons
•3. Contra-indications to performing lung function testing
•* Aortic aneurysm \>6cm
•* Unstable cardiovascular disease (unstable angina, myocardial infarction or pulmonary embolism \<4 weeks prior)
•* Severe aortic stenosis
•* Pneumothorax
•* Cerebral aneurysm
•* Thoracic or abdominal surgery \<4 weeks prior
•4. Contra-indications to passing oesophageal balloons
•* Oesophageal ulceration or varices
•* Sinusitis, recent nasal surgery or epistaxis