Efficacy of Intra-articular Injection of Human Amniotic Suspension Allograft and Platelet-rich Plasma in the Treatment of Knee Osteoarthritis.

Exclusion Criteria

• •Lawrence stage IV
• •Major axial deviation (varus\> 5°, valgus \> 5°)
• •Any concomitant symptomatic knee disorder (i.e. ligamentous/ meniscal injury)
• •Systemic inflammatory arthropathy
• •Hematologic diseases
• •Severe cardiovascular disease
• •Neurological disorders
• •Active infection
• •Immuno-compromised
• •Therapy with anticoagulants or antiaggregants
• •Use of NSAIDs and/or chondroprotective supplements, such as glucosamines and chondroitin sulfates, within 7 days prior to trial
• •Recent intra-articular injection of corticosteroids (within 30 days)
• •Prior treatment with HA in past 6 monthsHb\< 11 g/dL
• •Platelet count \< 150,000/mm3