Diagnosis of primary hypertension on treatment for at least 12 months with an ACEI or ARB-II in monotherapy.
Able to understand the study objectives and to provide written informed consent.
You may not be if
Severe hypertension, defined as a sitting systolic blood pressure ≥200 mmHg, a sitting diastolic blood pressure ≥115 mmHg or a maximum-minimum difference of ≥20 mmHg in systolic blood pressure or ≥10 mmHg in diastolic blood pressure between the right and left arms after three measurements on each arm.
Suggestive symptoms of secondary hypertension, such as abrupt onset hypertension, age \<30 years, advanced end organ damage, new-onset diastolic hypertension in the elderly,
Treated with antihypertensive drugs other than ACEIs or ARBs.
Use of drugs that affect diuresis or natriuresis.
Poorly controlled type 1 or 2 diabetes, defined as a fasting blood glucose ≥200 mg/dl or HbA1c ≥9%.
History of cardiovascular disease, defined as acute myocardial infarction, ischemic transient attack or stroke, congestive heart failure, peripheral vascular disease or cardiac arrhythmias.
Chronic obstructive pulmonary disease.
Liver or kidney disease.
Pregnant or lactating women.
Legal incapacity or impossibility to understand the study objectives.
Clareo Health | Salt Intake, Microbiota, Immune Response and Endothelial Function in Hypertension
