Effects of Auditory Brain Stimulation by "Pink Noise" on Memory Capacities in Alzheimer's Disease: Proof of Concept Study

Inclusion Criteria

• •Age\> 50 years at the inclusion
• •Patient with regular sleep patterns
• •Patient having given written consent
• •Patient affiliated to a social security regimen
• •Patient with a beginning Alzheimer's disease defined according to the criteria of the National Institute on Aging-Alzheimer's Association or carriers of a prodromal Alzheimer's disease defined according to the criteria of the International Working Group IWG-2; the diagnosis must be supported by brain imaging and a blood test carried out in routine care
• •MMSE score ≥ 24
• •Absence of neurodegenerative pathologies
• •Matched in age (+/- 5 years) and in sex with a patient
• •Psychiatric pathologies (except depression or anxiety disorders stabilized for more than 3 months)
• •History of pathology which may have consequences on cognitive functioning and / or sleep: brain tumor, constituted stroke, epilepsy, head trauma (with clinical or parenchymal sequelae objectified on brain imagery), brain surgery
• •Any significant comorbidity likely to constitute a confounding factor according to the clinician
• •Psychotropic treatments introduced or modified \<3 months before inclusion
• •Hypnotic and / or sedative treatments
• •Chronic consumption of alcohol or drugs
• •Legal incapacity and / or other circumstance rendering the patient unable to understand the nature, objective or consequences of the study
• •Major under guardianship or curatorship
• •Patient not French-speaking by birth or illiterate