Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)
Age
60–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Diagnosis of aMCI according to the NIA-AA criteria (Albert et al., 2011) and positive state of plasma p-tau217.
Diagnosis of aMCI according to the NIA-AA criteria (Albert et al., 2011) and negative state of plasma p-tau217 for aMCI negative group.
Cognitively unimpaired older subjects aged ≥ 65 years, Mini-mental state examination ≥28, and negative for plasma p-tau217.
You may not be if
Diagnosis of dementia due to AD or any other type of dementia.
Presence of any diagnosed sleep disorder such as narcolepsy, severe insomnia, severe obstructive sleep apnea, or severe chronic lack of sleep.
Hearing problems.
Analphabet individuals.
Comorbidities such as cancer, severe depression, severe renal or hepatic insufficiency, history of seizures, and severe cardiac or respiratory failure.
Alcohol and substance abuse.
Magnetic resonance imaging (MRI) evidence of stroke, hydrocephalus, a space-occupying lesion, or any clinically relevant central nervous system disease.
Existence of untreated (or treated for less than 3 months prior to the screening visit) vitamin B12 or folate deficiency.
Presence of untreated thyroid disease.
Use of betablockers, antidepressants, neuroleptics, and hypnotics, within 15 days before conducting polysomnography.
