Acoustic Stimulation During Sleep: Effects on Memory and p-tau217 in MCI

Exclusion Criteria

• •Diagnosis of dementia due to AD or any other type of dementia.
• •Presence of any diagnosed sleep disorder such as narcolepsy, severe insomnia, severe obstructive sleep apnea, or severe chronic lack of sleep.
• •Hearing problems.
• •Analphabet individuals.
• •Comorbidities such as cancer, severe depression, severe renal or hepatic insufficiency, history of seizures, and severe cardiac or respiratory failure.
• •Alcohol and substance abuse.
• •Magnetic resonance imaging (MRI) evidence of stroke, hydrocephalus, a space-occupying lesion, or any clinically relevant central nervous system disease.
• •Existence of untreated (or treated for less than 3 months prior to the screening visit) vitamin B12 or folate deficiency.
• •Presence of untreated thyroid disease.
• •Use of betablockers, antidepressants, neuroleptics, and hypnotics, within 15 days before conducting polysomnography.