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Prospective Longitudinal Study to Characterize and Understand the Clinical Relevance of SARS-CoV2 Related Ventilation and Perfusion Injury Evaluated by V/Q SPECT-CT in an Asthmatic and Healthy Population
Little is currently known about the immediate and long-term effect of COVID-19 on lung ventilation (delivery of air to the lungs) and lung perfusion (delivery of blood to the lungs). Some people who survive COVID-19 may have lung ventilation and/or perfusion injury that persists following COVID-19 recovery. This lung injury may be related to inflammation in the lung, breathlessness, exercise limitation and reduced quality of life. Therefore, towards the goal of understanding the effects of COVID-19 on lung health, the purpose of this study is to characterize and understand the clinical relevance of COVID-19 related lung ventilation and perfusion injury and associated inflammatory status, ≤4 weeks and 6-months following COVID-19 recovery in an asthmatic and healthy population. To do this, an asthmatic and healthy population who have, and have not, been previously diagnosed with COVID-19 will be studied.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
Yes
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada
Start Date
October 18, 2020
Primary Completion Date
January 26, 2022
Completion Date
January 26, 2022
Last Updated
August 14, 2025
42
ACTUAL participants
V/Q SPECT-CT
OTHER
St. George's Respiratory Questionnaire (SGRQ)
OTHER
mMRC (Modified Medical Research Council) Dyspnea Scale
OTHER
Six-minute walk test (6MWT)
OTHER
Spirometry
OTHER
Plethysmography & DLCO
OTHER
Airwave Oscillometry
OTHER
Lead Sponsor
McMaster University
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT07486401