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Effect of Total Sleep Deprivation on Vascular Function | Clinical Trials | Clareo Health

COMPLETEDNA

Effect of Total Sleep Deprivation on Vascular Function

NCT04535219•University of Florida

Summary

Insufficient sleep is associated with an increased risk for cardiovascular disease. The causal mechanisms are currently unknown, but may include endothelial dysfunction. The purpose of this study is to examine the influence of sex and aging on the effects of total sleep deprivation on vascular function and whether exercise training attenuates these effects.

Eligibility

Age

20 - 60 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Males and females
•20 to 30 and 50 to 60 years of age
•Females will be eumenorrheic at enrollment or postmenopausal for at least 1 year
•No major clinical disease (e.g., diabetes, cardiovascular, liver or chronic kidney disease) to minimize confounding of vascular measures
•Participants will be sedentary (≤3x per week of ≤30 minutes of aerobic exercise/session) or trained (≥5x per week of moderate/vigorous aerobic exercise training)

Exclusion Criteria

•Age \<20 or 31 to 49 or \>60 years
•Body mass index ≥30 kg/m\^2 because obesity may affect vascular function
•Use of medication that may affect vascular measures
•Hormone replacement therapy or hormonal contraceptives within past year
•Use of tobacco products (chewing tobacco, traditional or e-cigarettes) because they may influence vascular function
•Being perimenopausal, pregnant or lactating because may influence vascular function
•Being a shift worker because habitual sleep deprivation and altered circadian rhythm may influence vascular function.
•Not having an "intermediate" chronotype based on the Morningness-Eveningness Questionnaire (MEQ; score \<31 or \>69) because this would influence the effect of overnight sleep deprivation on vascular function.
•Sleep complaints based on the Pittsburgh Sleep Quality Index (PSQI; score \>5) because this would influence the effect of overnight sleep deprivation on vascular function.

Locations (1)

University of Florida

Gainesville, Florida, United States

Key Dates

Start Date

July 11, 2021

Primary Completion Date

August 2, 2022

Completion Date

August 2, 2022

Last Updated

August 29, 2023

Enrollment

ACTUAL participants

Conditions

Sleep Deprivation

Interventions

Exercise

OTHER

Supervised Total Sleep Deprivation

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 29, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effect of Total Sleep Deprivation on Vascular Function

Inclusion Criteria

Exclusion Criteria

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