Very Severe Malaria Treated by Intravenous Artesunate

Inclusion Criteria

• •More than 18 year-old at the time of inclusion AND
• •Hospitalization in the ICU AND
• •For severe imported malaria (Plasmodium falciparum) AND
• •Very Severe Malaria episode defined during the 72 first hours as :
• •* Neurological failure: Glasgow Coma Scale score\<11 or repeated convulsions and/or
• •* Shock: Systolic Blood Pressure\<80 mmHg despite adequate fluid loading or need for vasoactive drugs and/or
• •* Respiratory distress: Mechanical Ventilation or Non Invasive Ventilation ; or if spontaneous breathing: arterial pO2\<60 mmHg or pulse oxymetry\<92% in room air ; or Respiratory Rate\>32/min and/or
• •* Acidosis: plasma bicarbonate \<15 mmol/l, or pH\<7,35 and/or
• •* Hyperlactatemia \> 5 mmol/l and/or
• •* Death during hospitalization for VSM