Severe and Cerebral Malaria Investigated Through Host Metabolomics

* The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies. * Despite treatment between 10-30% of patients with severe malaria die. * Metabolic acidosis and cerebral malaria are major complications associated with mortality across all age groups. Still, their underlying pathogenesis remains incompletely understood. * Using a metabolomics approach, this study aims to characterise the spectrum of acids accumulating during acidosis, and investigate patterns of metabolic dysregulation associated with coma and seizures.