Comparison of Efficacy in SBRT of Large HCC With or Without TACE

Inclusion Criteria

• •primary HCC diagnosed by a surgeon and/or radiologist and oncologist according to the international guidelines for the management of HCC or by pathology
• •single lesion and longest tumor diameter were 5-10cm;
• •CP-A or B classification;
• •Eastern Cooperative Oncology Group (ECOG) score 0-1;
• •distances between tumor and normal organs (esophagus, stomach, duodenum, bowel) are more than 5 mm
• •unsuitable for other therapies, such as patients with heart disease, uncontrolled diabetes, uncontrolled hypertension, etc.
• •rejecting other therapies such as resection, liver transplantation, etc.
• •platelet count≥50 × 109/L, white blood count≥1.5 × 109/L;
• •patients infected with hepatitis B virus who are treated with adefovir or entecavir; patients infected with hepatitis C virus whose HCV DNA are negative.