Radiotherapy Combined With GDP With or Without Chidamide in Stage I/II Extranodal Nasal NK/T-cell Lymphoma

Inclusion Criteria

• •1. Diagnosis of NKTCL with typical morphology and immunophenotype, according to the 2008 World Health Organization classification of lymphomas;
• •2. no prior radiotherapy or chemotherapy;
• •3. age ≥ 18 years;
• •4. ECOG performance status 0-2;
• •5. Ann Arbor stages I and II;
• •6. tumors primarily occurring in the upper aerodigestive tract;
• •7. at least one unfavorable prognostic factor (age \> 60 years, B symptoms, elevated LDH, ECOG score 2, regional node involvement, and PTI);
• •8. at least one measurable lesion;
• •9. adequate hematological, hepatic, and renal functions; e.g., absolute neutrophil count ≥ 1.5 × 109/L, platelet count ≥ 80 × 109/L, total bilirubin ≤ 1.5 × upper limit of normal, alanine transaminase and aspartate transaminase ≤ 2 × upper limit of normal, and creatinine ≤ 1.5 mg/dl;
• •10. life expectancy of more than 3 months.