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COMPLETED

Prospective Clinical Study of Retinal Microvascular Alteration After ICL Implantation

NCT04443231•Peking University Third Hospital

Summary

To observe the retinal microvascular alteration during 3 months follow-up after Implantable Collamer Lens (ICL) operation in moderate and high myopia patients using quantitative optical coherence tomography angiography (OCTA) analysis.

Detailed Description

The study object is moderate and high myopia patients, underwent ICL implantation. OCTA was used to image the superficial and deep retinal vascular plexuses before ICL implantation surgery and at 3 months follow-up. OCTA images were corrected for magnification, skeletonized, separated the large vessels and partitioned. Retinal microvascular density was measured by using fractal dimension analysis. The aim of this study was to uncover potential retinal vascular network alterations induced by ICL implantation surgery.

Eligibility

Age

18 - 45 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•18 to 45 years old;
•Binocular myopia, with a refraction of greater than -3 diopters (D);
•anterior chamber depth (ACD, measured from the endothelium to the crystalline lens) \> 2.8 mm;
•corneal endothelial cell count (cECC) ≥ 2000 cells/mm2;
•stable refraction at least 1 year before surgery;
•unsatisfactory vision with contact lenses or spectacles.

Exclusion Criteria

•history of intraocular surgery
•other ocular pathology (uveitis, glaucoma, cataract, keratoconus, severe dry eye, etc.)
•other serious systemic disease (diabetes, uncontrolled hypertension, severe hyperthyroidism, etc.).

Locations (1)

Peking University Third Hospital

Beijing, Beijing Municipality, China

Key Dates

Start Date

November 1, 2018

Primary Completion Date

October 1, 2019

Completion Date

October 1, 2019

Last Updated

June 23, 2020

Enrollment

ACTUAL participants

Conditions

AdolescentAdultHumanMaleFemaleFollow-up StudiesProspective StudiesLens Implantation, IntraocularMyopiaPhakic Intraocular LensesRetinal VesselsPostoperative PeriodPreoperative PeriodTomography, Optical Coherence

Interventions

Optical Coherence Tomography Angiography

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 23, 2020Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Prospective Clinical Study of Retinal Microvascular Alteration After ICL Implantation

Inclusion Criteria

Exclusion Criteria

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