Study of VIR-3434 in Healthy Volunteers and Patients With Chronic Hepatitis B Virus Infection

Exclusion Criteria

• •Any clinically significant chronic or acute medical condition that makes the volunteer unsuitable for participation
• •History or evidence of drug or alcohol abuse
• •History of allergic reactions to monoclonal antibodies or antibody fragments
• •History of anaphylaxis
• •CHB Patients:
• •Any clinically significant chronic or acute medical condition that makes the participant unsuitable for participation
• •Significant fibrosis or cirrhosis
• •History or evidence of drug or alcohol abuse
• •History of chronic liver disease from any cause other than chronic HBV infection
• •History of hepatic decompensation
• •History of anaphylaxis
• •History of allergic reactions to monoclonal antibodies or antibody fragments
• •History of immune complex disease
• •Active infection with HIV, HCV or hepatitis Delta virus