FEV1 \< 80% in the last 12 months

use of high dose inhaled corticosteroids (ICS) in combination with other additional medication or continuous use of oral corticosteroids (OCS)

at least 2 exacerbations in the last 12 months

at least 300 blood eosinophils/µl once in the last 12 months and at the time of inclusion

Anti-IL5 treatment prescribed by the physician

Effect of Anti-interleukin 5 (IL5) Therapy on Sputum Cells and Cytokines