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Bioactive Glass in the Treatment of Enamel White Spot Lesions | Clinical Trials | Clareo Health

COMPLETEDPHASE3

Bioactive Glass in the Treatment of Enamel White Spot Lesions

Effectiveness of Novel Bioactive Glass in the Treatment of Enamel White Spot Lesions : A Randomized Controlled Trial

NCT04401280•Rania Salah

Summary

the aim of this study is to evaluate the effectiveness of BiominF® and Novamin® in comparison to Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in the treatment of enamel white spot lesions

Eligibility

Age

14 - 26 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Not less than 1 white spot lesion on the labial surface of teeth in the anterior region with code 2 International Caries Detection and Assessment System II (ICDAS-II) or less
•Absence of any active periodontal disease.
•Written informed consent

Exclusion Criteria

•Known hypersensitivity/allergy to study products and/or materials used
•teeth having deep carious lesions or extensive restorations
•Unwillingness to be randomly assigned to 1 of the 3 treatment groups
•Advanced periodontal disease.

Locations (1)

Faculty of Dentistry

Alexandria, Egypt

Key Dates

Start Date

June 1, 2020

Primary Completion Date

June 30, 2021

Completion Date

June 30, 2021

Last Updated

October 19, 2021

Enrollment

ACTUAL participants

Conditions

White Spot Lesion of Tooth

Interventions

BiominF

DRUG

Novamin

DRUG

CPP-ACP

DRUG

Remineralization Potential of PRG Barrier Coat Versus Fluoride Varnish in White Spot Lesions in Permanent Anterior Teeth of Children

NCT06986551

White Spot Lesion of ToothDemineralization

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NOT_YET_RECRUITINGPHASE2

Preventive Effects of Silver Diamine Fluoride on Early Enamel Caries

NCT06797882

Demineralization, ToothWhite Spot Lesion of Tooth+2 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 19, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Bioactive Glass in the Treatment of Enamel White Spot Lesions

Inclusion Criteria

Exclusion Criteria

Remineralization Potential of PRG Barrier Coat Versus Fluoride Varnish in White Spot Lesions in Permanent Anterior Teeth of Children

Preventive Effects of Silver Diamine Fluoride on Early Enamel Caries

Efficacy of Different Agents in Treatment of Initial Caries on Smooth Surfaces in Permanent Teeth in Children

Treatment of Postorthodontic White Spot Lesions