Proof-of-concept Study of LymphMonitor 1.0 to Assess the Lymphatic Vessel Function

Exclusion Criteria

• •critical illness (active cancer, renal failure, hepatic dysfunction)
• •active infection
• •blood vascular malformations or diseases
• •scleroderma
• •primary lymphedema
• •patients who underwent any surgical procedures for treatment of lymphedema (e.g. lymphovenous anastomosis, liposuction, lymph node transfer).
• •contraindications to use ICG (VERDYE), i.e.
• •patients with hypersensitivity to ICG or to sodium iodide
• •patients with hypersensitivity to iodine,
• •patients with hyper-thyroidism, patients with autonomic thyroid adenomas
• •patients in which the injection of VERDYE was poorly tolerated in the past it must not be used again, since severe anaphylactic reactions might occur.
• •hypersensitivity to albumin or its excipients
• •women, who are pregnant (pregnancy test will be performed in case of women who did not undergo menopause),
• •women who are breast feeding ,
• •enrolment of the investigator, his/her family members, employees and other dependent persons,
• •known or suspected non-compliance, drug or alcohol abuse,
• •inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant,
• •participation in another study with investigational drug within the 30 days preceding and during the present study,
• •previous enrolment into the current study.