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Women with androgen excess polycystic ovary syndrome (AE-PCOS) leads to hypertension.
Our scientific premise is that in AE-PCOS women, the androgen-dominant hormonal milieu causes BP increases via sympathetic activation, vasoconstriction and renal sympathetic nervous system activation. Moreover, this androgen-dominant milieu increases BP via activation of the renin-angiotensin system.
Age
18 - 35 years
Sex
FEMALE
Healthy Volunteers
Yes
The John B Pierce Laboratory
New Haven, Connecticut, United States
Start Date
December 1, 2017
Primary Completion Date
June 30, 2022
Completion Date
June 30, 2022
Last Updated
February 2, 2024
28
ACTUAL participants
GnRH antagonist
DRUG
GnRH antagonist + MethylTESTOSTERone 5 MG
DRUG
Lead Sponsor
Yale University
Collaborators
Data Source & Attribution
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