Lead Sponsor

University of California, Los Angeles

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

•in good general health (as evaluated during the phone and in-person screening sessions)
•aged 18-65 years
•if female, using adequate birth control

•history of hypersensitivity to xanthine derivatives (a contraindication to theophylline treatment)
•pregnant or planning to become pregnant in the next 6 months
•current breastfeeding
•chronic diseases such as cardiovascular disease, hepatic impairment, peptic ulcer disease, and seizure disorders
•current use of prescription medications such as steroids, non-steroid anti-inflammatory drugs, immune modifying drugs, opioid analgesics, and psychotropics
•Axis I psychiatric disorders including current major depressive disorder
•current depressive symptoms assessed by the Patient Health Questionnaire (PHQ-9 ≥ 5)
•heavy smoking (1 pack or more per day)
•excessive caffeine use (\>600 mg/day)
•Body-mass index \> 35 due to the effects of obesity on cytokine activity
•evidence of recreational drug use from urine test
•evidence of pregnancy from urine test
•evidence of clinically significant rhythm abnormality on a resting electrocardiogram (ECG)
•clinically significant abnormalities on screening laboratory tests