Examining the Role of the Orexin System in Sleep and Stress in Persons With Opioid Use Disorder

Exclusion Criteria

• •Serious mental illnesses that are unstable and could affect study participation (thought disorders, hallucinations, delusions, thoughts of harm to self/others).
• •Current moderate to severe substance use disorder other than OUD.
• •Current illicit stimulant use, including cocaine and methamphetamine.
• •Pregnant or breast feeding.
• •Have a known allergy to the study medications.
• •Past 30-day prescribed use of suvorexant.
• •Current use of a benzodiazepine or other schedule IV medication for insomnia.
• •Use of Cytochrome P450 3A inhibitors.
• •Current narcolepsy, sleep paralysis, or restless leg syndrome as assessed by medical history
• •Apnea-hypopnea index \> 30.
• •Use of glucocorticoid medications and any medication that would alter the hypothalamic-pituitary-adrenal axis.
• •Past 30-day suicidal behavior as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS).
• •Have circumstances that would interfere with study participation (e.g., impending jail; severe clinical issues).