Lead Sponsor

University Hospital, Geneva

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Subject is ≥18 years of age.
•Subject must be willing to sign a Patient Informed Consent (PIC).
•Coronary artery disease with over 50% angiographic diameter stenosis on visual assessment, undergoing clinically indicated invasive physiological assessment by means of FFR.
•Assessment of non culprit arteries with over 50% angiographic diameter stenosis on visual assessment, in patients presenting with NSTEMI.

•Pregnant and/or breastfeeding females.
•Known allergies to: heparin, contrast medium, adenosine.
•Contra-indication to adenosine.
•Severe renal failure (eGFR ≤ 30 ml/min/m2).
•Ostial stenosis in both the left and right coronary arteries.
•Presence of a chronic total occlusion.
•History of coronary artery bypass graft.
•Acute coronary syndrome.
•Acute myocardial infarction within the preceding two weeks.
•Severe valvular heart disease.
•Left main disease.
•Documented left ventricular ejection fraction (LVEF) ≤30% as documented within maximum 6 months prior to the procedure.
•Decompensated congestive heart failure.
•Extreme hypotension (systolic blood pressure \<100 mmHg)
•Extreme bradycardia (\<40 bpm).