Comparison of Optical Coherence Tomography-derived Minimal Lumen Area, Invasive Fractional Flow Reserve and FFRCT

Exclusion Criteria

• •Significant distal lesions (\>50% angiographic DS on visual estimation within the left anterior descending artery \[LAD\] or left circumflex artery \[LCX\], except for ostium of LAD or LCX or diseased side branch \[e.g. diagonal branch, obtuse marginal branch\])
• •Ostial LM disease.
• •Acute coronary syndrome (ACS) (non-ST-elevation ACS and ST-elevation MI).
• •LM In-stent restenosis.
• •Previous coronary stenting of the left coronary system.
• •Chronic total occlusion.
• •Previous coronary artery bypass graft.
• •Previous MI related to the left coronary artery.
• •Occurrence of ventricularization or hypotension during engagement of the LM ostial lesion.
• •The presence of hemodynamic instability.
• •Known renal insufficiency (serum creatinine \>1.5mg/dL or receiving dialysis).
• •Female of childbearing potential (age \<50 years and last menstruation within the last 12 months), who did not undergo tubal ligation, ovariectomy or hysterectomy.
• •Life expectancy less than 1 year.
• •Contraindication or known allergy against protocol-required medications including heparin, iodinated contrast, β-blocker, nitroglycerin, and adenosine.
• •Body mass index \>35kg/m2.
• •Complex congenital heart disease other than anomalous coronary origins alone.
• •Ventricular septal defect.