Sintilimab Combined With Bevacizumab for Brain Metastases From Non-small Cell Lung Cancer

Exclusion Criteria

• •1. Mixed non-small cell and small cell carcinoma;
• •2. Brain metastasis with hemorrhage;
• •3. Currently participating in interventional clinical research and treatment, or receiving other research drugs or using research instruments within 4 weeks before the first dose;
• •4. Previously received the following therapies: anti-PD-1, anti-PD-L1 or anti-PD-L2 drugs or drugs targeting another stimulation or synergistic inhibition of T cell receptors (e.g., CTLA-4, CD137);
• •5. Received solid organ or blood system transplantation;
• •6. Received \>30GY pulmonary radiotherapy 6 months before the first dose;
• •7. Active autoimmune diseases requiring systemic treatment (such as the use of disease-relieving drugs, corticosteroids or immunosuppressants) occurred within 2 years before the first dose.Alternative therapies (such as thyroxine, insulin, or physiological corticosteroids for adrenal or pituitary insufficiency) are not considered systemic;
• •8. Received systemic glucocorticoid therapy or any other form of immunosuppressive therapy within 7 days before the first dose of the study or diagnosed as immunodeficiency;a physiological dose of glucocorticoid (10 mg/ day of prednisone or equivalent) is permitted;
• •9. History of non-infectious pneumonia requiring glucocorticoid therapy or current interstitial pulmonary disease was found within 1 year before the first dose;
• •10. History of human immunodeficiency virus (HIV) infection (i.e. HIV 1/2 antibody positive)
• •11. Untreated active hepatitis;
• •12. History of hemoptysis within 3 months prior to selection, that is, at least 1/2 teaspoon of blood was coughed up;
• •13. Imaging showed signs of tumor invasion into the great vessels.The investigator or radiologist must rule out patients whose tumors have completely approached, wrapped, or invaded the intravascular space of the great vessels
• •14. Serious uncontrolled coagulation disorder or thrombi-embolic complications within 6 months prior to study start or history of serious bleeding complications.
• •15. Major surgical procedures within 4 weeks prior to study entry.
• •16. Minor surgery, including insertion of an indwelling catheter, within 24 hours prior to the first bevacizumab infusion.
• •17. Non-healing wound, active peptic ulcer or bone fracture.
• •18. History of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 6 months of enrollment