Ning bo Liu, M.D., Ph.D

CONTACT

Lead Sponsor

Tianjin Medical University Cancer Institute and Hospital

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

•Patients with limited small cell lung cancer diagnosed by histopathology;
•ECOG 0-1 points;
•Weight ≥ 45 kg;
•Age 18-75 years old;
•It is expected that at least 2 cycles of EP chemotherapy will be completed as planned; once thiophene penicillin is used, chemotherapy should not be re-dosed within 12 days.
•Bone marrow hematopoietic function is normal, no bleeding tendency (INR\<1.5);
•Laboratory tests are subject to: (1) Blood routine examination: Hb≥90g/L; WBC≥4.0×109/ L; ANC≥2.0×109/L; PLT≥100×109/L. (2) Liver function, biochemical examination: ALT and AST≤1.5×ULN; TBIL≤1.5×ULN; Serum creatinine≤1.5×ULN.
•According to the researcher's judgment, the test plan can be observed;
•Volunteer to participate in this clinical trial, understand the research process and be able to sign informed consent in writing.

•There are currently uncontrolled infections or systemic antibiotics within 72 hours of receiving chemotherapy;
•Any abnormal bone marrow hyperplasia and other hematopoietic dysfunction;
•Patients who have received bone marrow or hematopoietic stem cell transplantation within the past 3 months;
•Patients with previous malignant tumors that have not been cured or have brain metastases;
•Liver function tests Total bilirubin (TBIL), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) are \>2.5 times the upper limit of normal; if due to liver metastasis, the above indicators are \>5 times the upper limit of normal;
•Renal function test: serum creatinine (Cr) \> 1.5 times the upper limit of normal;
•Those who are allergic to this product;
•suffering from mental or neurological disorders that cannot be matched;
•Female patients during pregnancy or lactation; women of childbearing age who refuse to receive contraception;
•The investigator believes that it is not suitable for inclusion.