Pharmacometabolomics of Andrographis Paniculata And Metformin In Healthy Volunteers Under Fasting Condition

Exclusion Criteria

• •1. Volunteers suffering from any chronic illness such as arthritis, asthma, etc.
• •2. History of pre-existing bleeding disorder.
• •3. Clinically relevant abnormalities in the results of the laboratory screening evaluation.
• •4. Clinically significant abnormal electrocardiogram (ECG).
• •5. Positive HIV or positive hepatitis B or C in screening test or no known other hepatitis infection.
• •6. History of significant blood loss due to any reason, including blood donation in the past 3 months.
• •7. Participation in any study within past 3 months
• •8. History of alcohol or drug abuse
• •9. History of consumption of prescribed medication since last 14 days or Over-the-counter medication/ herbal remedies since last 7 days before beginning of the study.
• •10. Systolic blood pressure less than 100 mmHg or more than 139 mmHg and diastolic blood pressure less than 60 mmHg or more than 89 mmHg.
• •11. Pulse rate less than 60/minutes or more than 100/minute unless deem not clinically significant by investigator.
• •12. Oral temperature more than 37.5 degree Celsius.
• •13. History of allergy to the investigational product or any drug chemically similar to the drug under investigation.
• •14. Recent history of kidney or liver dysfunction.
• •15. Volunteers suffering from any psychiatric (acute or chronic) disorder.
• •16. Existence of any surgical or medical condition, which, in the judgment of the chief investigator and/or clinical investigator/physician, might interfere with the absorption, distribution, metabolism or excretion of the drug or likely to compromise the safety of volunteers.
• •17. Inability to communicate or co-operate.