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Antibiotic Dosing in Pediatric Intensive Care | Clinical Trials | Clareo Health

RECRUITING

Antibiotic Dosing in Pediatric Intensive Care

NCT02456974•University Hospital, Ghent

View on ClinicalTrials.gov

Summary

Pharmacokinetics of antibiotics in critically ill neonates, infants and children

Eligibility

Age

0 - 16 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•patients admitted to the pediatric intensive care unit
•patient age/weight : 1,8 kg-15 years
•patient receiving antibiotic treatment (piperacillin-tazobactam, amoxicillin-clavulanate, vancomycin, teicoplanin, meropenem, ciprofloxacin, amikacin) via intermittent infusion regimen or continuous infusion according to institutional treatment guidelines
•intra-arterial or intravenous access other than the drug infusion line available for blood sampling (arterial line is preferred)

Exclusion Criteria

•no catheter in place for blood sampling
•absence of parental/patient consent
•known hypersensitivity to beta-lactam antibiotics, glycopeptides, fluoroquinolones, aminoglycosides
•extracorporeal circuit (haemodialysis, ECMO, peritoneal dialysis )

Locations (1)

Ghent University Hospital, Hospital Pharmacy

Ghent, Belgium

Key Dates

Start Date

May 1, 2012

Primary Completion Date

September 1, 2027

Completion Date

September 1, 2027

Last Updated

January 16, 2026

Enrollment

640

ESTIMATED participants

Conditions

PharmacokineticsAmoxicillin-clavulanatePiperacillin-tazobactamVancomycinTeicoplaninMeropenemCiprofloxacinAmikacin

Interventions

blood sampling in patients receiving amoxicillin-clavulanate as part of routine clinical care

PROCEDURE

blood sampling in patients receiving piperacilline-tazobactam as part of routine clinical care.

PROCEDURE

blood sampling in patients receiving vancomycin as part of routine clinical care.

PROCEDURE

blood sampling in patients receiving teicoplanin as part of routine clinical care.

PROCEDURE

blood sampling in patients receiving meropenem as part of routine clinical care.

PROCEDURE

blood sampling and urine smapling in patients receiving ciprofloxacin as part of routine clinical care.

PROCEDURE

blood sampling in patients receiving amikacin as part of routine clinical care.

PROCEDURE

Contacts

Pieter De Cock, PharmD

CONTACT

+32 9 332 29 69 pieter.decock@uzgent.be

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 16, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Antibiotic Dosing in Pediatric Intensive Care

Inclusion Criteria

Exclusion Criteria

Investigating the Pharmacokinetics of Tafenoquine in Healthy Papua New Guinean Children

PK/PD of Caspofungin in Children Severe Infection

Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)

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