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COMPLETEDPHASE2

Neurocircuit Strategy to Decrease Cocaine Cue Reactivity

NCT04155632•Medical University of South Carolina

Summary

The overarching goal of this project is to examine the effect of combining theta burst stimulation (TBS) and N-acetylcysteine (NAC) on cocaine craving and brain response to cocaine-related images.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1\. Age 18-65 2. English fluency 4. Meet criteria for cocaine use disorder (CUD), as determined by DSM-V criteria, using the Structured Clinical Interview for DSM-V.
•5\. Enrolled in an intensive outpatient treatment program (MUSC Center for Drug and Alcohol Programs Intensive Outpatient Program (CDAP-IOP) or currently engaged in treatment for substance related problems.
•6\. Able to read and understand questionnaires and informed consent 7. Lives within 50 miles of the study site. 8. Is not at elevated risk of seizure (i.e., does not have a history of seizures, is not currently prescribed medications known to lower seizure threshold) 9. Does not have metal objects in the head/neck. 10. Does not have a history of traumatic brain injury, including a head injury that resulted in hospitalization, loss of consciousness for more than 10 minutes, or having ever been informed that they have an epidural, subdural, or subarachnoid hemorrhage.
•11\. Does not have a history of claustrophobia leading to significant clinical anxiety symptoms.

Exclusion Criteria

•1. Past head injury or primary neurological disorder associated with MRI abnormalities, including dementia, MCI, brain tumors, epilepsy, Parkinson's disease, or demyelinating diseases
•2. Any physical or intellectual disability affecting completion of assessments
•3. Any contraindication to MRI
•4. Current or past psychosis
•5. ECT in last 6 months
•6. Among females, pregnancy at screening will be exclusionary. Females of child bearing potential must agree to undergo a pregnancy test 72 hours prior to the fMRI scanning session and regularly before and during the medication trial. They must further agree to notify the study physician or PA if they become pregnant during the study.
•7. Clinical Institute Withdrawal Assessment (CIWA-Ar) scale will be used to assess alcohol withdrawal. Individuals with CIWA \> 8 will be excluded.
•8. Individuals with unstable medical illness (e.g., hypertension, diabetes, myocardial infarction)
•9. Has current suicidal ideation or homicidal ideation.
•10. Has the need for maintenance or acute treatment with any psychoactive medication including anti-seizure medications and medications for ADHD
+2 more criteria

Locations (1)

Medical University of South Carolina

Charleston, South Carolina, United States

Key Dates

Start Date

December 18, 2020

Primary Completion Date

March 9, 2023

Completion Date

March 9, 2023

Last Updated

September 24, 2025

Enrollment

ACTUAL participants

Conditions

Cocaine-Related Disorders

Interventions

N-acetylcysteine

DRUG

Theta-burst stimulation (TBS)

DEVICE

Targeting Anhedonia in Cocaine Use Disorder

NCT02773212

Cocaine-Related DisordersAnhedonia

View study

COMPLETEDEARLY_PHASE1

Brain Mechanisms in Young Adults

NCT03606473

Cocaine-Related Disorders

View study

TERMINATEDPHASE1

Dopamine Reuptake Inhibitors of Cocaine Abuse - 1

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 24, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Neurocircuit Strategy to Decrease Cocaine Cue Reactivity

Inclusion Criteria

Exclusion Criteria

Targeting Anhedonia in Cocaine Use Disorder

Brain Mechanisms in Young Adults

Dopamine Reuptake Inhibitors of Cocaine Abuse - 1

Treatment of Heroin and Cocaine With Methadone Maintenance and Contingency Management

Aripiprazole for Prevention of Relapse to Cocaine Use in Methadone-Maintenance Patients

Evaluation of N-Acetylcysteine Efficacy to Reduce the Craving and to Prolong Abstinence Time of Coca Paste