Targeting Anhedonia in Cocaine Use Disorder

Exclusion Criteria

• •current DSM-5 diagnosis for substance use disorder of least moderate severity (≥ 4 symptoms), other than cocaine, nicotine, marijuana, or alcohol
• •Physical dependence on alcohol requiring medically supervised detoxification, in the judgment of the study physician
• •current amphetamine use (by self-report in past 30 days or positive urine drug screen), more than 50 lifetime uses of amphetamine, or history of DSM-5 Amphetamine Use Disorder
• •a current DSM-5 axis I psychiatric disorder or neurological disease or disorder requiring ongoing treatment and/or making study participation unsafe
• •significant current suicidal or homicidal ideation
• •medical conditions contraindicating d-amphetamine (e.g., significant cardiovascular disease, liver or kidney disease, seizure disorder, hypotension or hypertension)
• •taking medications known to have effects on the central nervous system or that could cause significant drug interactions with d-amphetamine (e.g., clonidine, prazosin)
• •having conditions of probation or parole requiring reports of drug use to officers of the court
• •impending incarceration
• •pregnant or nursing for female patients
• •inability to read, write, or speak English
• •body mass index (BMI) \>30, as this may be incompatible with the magnetic resonance scanner gantry
• •any retained metals in the body, including implants and metallic substances (e.g. aneurysm clips, retained metal particles in metal workers, magnetic dental implants, ferromagnetic ocular implants, iron-based facial tattoos), as this may cause adverse effects to participants and interfere with data collection in the MR magnetic field
• •inability to tolerate small, enclosed spaces (such as the magnetic resonance scanner bore)