Age

18–80

Sex

ALL

Healthy volunteers

Accepted

Aged 18 - 80 years old
Able to give informed consent
All patients identified as being suitable for anti-IL5 therapy by the asthma MDT will be considered for study enrolment.
This assessment by the MDT for participants to be eligible includes:
A measure of compliance with current asthma medication,
Confirmation of asthma diagnosis
Suitability for anti-IL5 therapy based on blood eosinophil counts,
Asthma exacerbation rates
Prednisolone dose.
Confirmation of treatment requires at least two asthma specialists to agree that this is the correct course of action
Patients must first demonstrate over 75% compliance with inhaled and/or oral corticosteroid therapy
The asthma MDT and difficult asthma clinic normally assess patients between 18-80 years so only patients in this age range will be approached.
All patients will be able to give informed consent for study participation.
Aged between 18-80 years old.
Able to give informed consent

Poor Response to Monoclonal Therapy in Asthma