Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease

Exclusion Criteria

• •Aim1 (CD participants)
• •1. B1 or B3 (i.e., fistula, abscess, phlegmon/inflammatory mass) CD phenotype
• •2. Prior small bowel surgery, including but not limited to surgical resection, stricturoplasty, or endoscopic treatment of a small bowel stricture
• •3. Anything to eat or drink within 4 hours of study visit (participants may take their required medications with a little water)
• •4. Known pregnancy (Note: Institutional policies/procedures will be followed for pregnancy screening)
• •5. Contraindication for MRI (e.g., surgical implant, claustrophobia). Note: To be determined based on local procedures.
• •Aim 2 (CD participants)
• •1. Stenotic ileocecal valve at colonoscopy
• •2. Prior small bowel surgery, including but not limited to surgical resection, stricturoplasty, or endoscopic treatment of a small bowel stricture
• •3. Anything to eat or drink within 4 hours of study visit (participants may take their required medications with a little water)
• •4. Known pregnancy (Note: Institutional policies/procedures will be followed for pregnancy screening)
• •5. Contraindication for MRI (e.g., surgical implant, claustrophobia). Note: To be determined based on local procedures.
• •Aim 2 (Control participants)
• •1. Any known gastrointestinal tract disease
• •2. Any known inflammatory/autoimmune disease involving another organ system (e.g., rheumatoid arthritis, scleroderma, multiple sclerosis).
• •3. Fecal calprotectin level of ˃100 mcg.gm will be excluded from further analysis and replaced.