Effects of Dapagliflozin on Hormonal Glucose Homeostasis in Type 1 Diabetes

Exclusion Criteria

• •Contraindications to SGLT-2 inhibitors
• •Contraindications to lactose
• •Diagnosis of renal and/or hepatic dysfunction
• •History of malignancy of any kind
• •Intake of drugs influencing glucose homeostasis during the last three months (steroids, metformin, sulfonylureas, thiazolidinedione)
• •Known or suspected non-compliance, drug or alcohol abuse.
• •Inadequate vein status on both forearms
• •Active smoker (defined as ≥1 or more cigarettes or nicotine-containing equivalents per day)
• •Known pregnancy, positive plasma beta-HCG test prior to study inclusion or intention to become pregnant during the study period.
• •Women who are breast feeding
• •Lack of safe contraception
• •Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant