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COMPLETEDEARLY Phase 1NCT04022226

EEG Characteristics in ECT

The investigators will be examining slow-wave characteristics in depressed patients receiving electroconvulsive therapy (ECT) using direct current electroencephalogram (dcEEG) by anesthesia induction ...

Lead sponsor: University of New Mexico•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of New Mexico

This is a pilot project using dcEEG to look at infra-slow waves in depressed patients receiving ECT randomized to ketamine or methohexital where ketamine suppresses infra-slow waves. The rationale for this project is to identify biomarkers of treatment adequacy in ECT, which could lead to decreased morbidity and mortality with the procedure and lessen the burden of depression in our patient population.

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Structured Clinical Interview for DSM-5 will confirm diagnosis of MDD or BPD-depressed (with or without psychotic features
•The clinical indications for ECT including treatment resistance or a need for a rapid and definitive response;
•Hamilton Depression Rating Scale 24-item (HDRS-24) \> 21; and
•Age range between 18 and 65 years of age.

Exclusion Criteria

•Defined neurological or neurodegenerative disorder (e.g., history of head injury with loss of consciousness \> 5 minutes, epilepsy, Alzheimer's disease);
•Other psychiatric conditions (e.g., schizophrenia, schizoaffective disorder, bipolar disorder)
•Current drug or alcohol use disorder, except for nicotine and marijuana
•Adults unable to consent, pregnant women, prisoner
•Non-English speakers
•Patients that cannot tolerate Methohexital and Ketamine.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: October 26, 2024Terms

Trial snapshot

StatusCOMPLETED

PhaseEARLY_PHASE1

Enrollment11

Start dateOct 2019

Last updatedOct 26, 2024

Condition

Electroconvulsive Therapy Direct Current Electroencephalogram Ketamine Spreadind Depression

Locations shown

University of New Mexico Mental Health Center

Albuquerque, New Mexico

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 26, 2024Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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