For Minimal Change Disease patients only, history of resistance to corticosteroid therapy
Increased urinary excretion of biomarkers of Tumor Necrosis Factor (TNF) activation (MCP1/Cr and/ or TIMP1/Cr) at study screening
eGFR\>30 ml/min/1.73 m2 at screening
Urine protein:creatinine ratio ≥1.5 g/g at screening
Weight \>15 kg
Stable therapy with angiotensin converting enzyme inhibitors, angiotensin receptor blockers, and oral immunosuppression agents for at least 30 days prior to enrollment
Birth control use in females of child bearing potential
Informed consent and assent if applicable
You may not be if
Kidney or other solid organ or bone marrow transplant recipient
Active local or systemic bacterial, fungal or viral infection
Active or latent Hepatitis B, Hepatitis C, HIV, or tuberculosis
History of demyelinating disease, e.g. Multiple Sclerosis or Guillain-Barre
History of heart failure
Active liver disease
Systemic lupus erythematosus or ANA \> 1:80
History of inflammatory bowel disease, e.g. ulcerative colitis or Crohns disease
Cyclophosphamide in past 90 days, Rituximab in the past 180 days
Pregnancy or nursing
Blood white blood cell count \<4,500/mm3; Hg \<9 g/dL; Platelet count \<150,000/mm3 at enrollment. - Use of an erythropoiesis stimulating agent will not be an exclusion criterion.
Concurrent use of interleukin-1 antagonist (Anakinra), other TNF blocking agent, methotrexate or abatacept
