Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Lingjiang Li
Age
18–60
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Adult (≥18 years, both sexes), with ICD-10 criteria for MDD without psychosis, as determined by a structured clinical interview Mini International Neuropsychiatric Interview
Moderate to severe depression, as defined by a pretreatment score \>17 on the HDRS-17 scale
TRD was defined as having had at least two adequate dose-duration, antidepressant medication failures in the current episode and a lifetime failure of at least three antidepressant medication trials.
Informed consent to participate in this study
You may not be if
A history of bipolar disorder, schizophrenia, schizoaffective disorder, obsessive-compulsive disorder, panic disorder, or documented Axis II diagnoses; active suicidal intention, as determined by clinical interview
Active or recent (\<12 months) substance abuse or dependence; excluding nicotine
Presence of acute medical illness that could interfere with study participation, including significant pulmonary disease
Acute severe suicidal ideation
Acute psychosis
Received ECT treatment within 6 months
History of NMDA-antagonists (e.g., ketamine) intake
Pregnancy or breastfeeding
Any contraindications to the use of nitrous oxide (e.g., pneumothorax, middle ear occlusion, elevated intracranial pressure, chronic cobalamin or folate deficiency unless treated with folic acid or vitamin B12).
Clareo Health | Nitrous Oxide for Major Depressive Disorder
