Study to Determine the Effect of Food on the Blood Levels of AST2818 Following Single Oral Doses in Healthy Male Volunteers

Exclusion Criteria

• •1. The participants have history of chronic disease and serious illness in vascular system, blood system, urinary system, respiratory system, digestive system, nervous system, skin system and psychiatric disorders, any conditions and illness threat to the health of participants, and the history of hereditary disease.
• •2. The participants have history of similar drug, allergy history to similar drug, allergic disorders and allergic constitution.
• •3. The participants having history of drug abuse，opioid and tranquillizer， drug addicts, or drug screening for someone was positive.
• •4. Resting corrected electrocardiogram QT interval using Fridericia's correction factor (QTcF) \>470 msec within screening period.
• •5. Any factors that increase the risk of prolonging QTc and abnormality in heart rate, i.e., heart failure, hypokalemia, congenital long QT syndrome, a family history of long QT syndrome or unreasonable sudden death at age smaller than 40 in first-degree relatives, administrating any combined medicines that possibly prolong QT interval
• •6. Severe disease of respiratory system, i.e., interstitial lung disease and severe asthma, etc.
• •7. Severe disease of ophthalmic system, e.g., corneal diseases;
• •8. The participants have severe infection, severe trauma or major surgery within 1 year before screening;
• •9. The participants have history of alcohol abuse (it was defined as that the daily alcohol consumption was higher than the following criteria: the weekly alcohol consumption was higher than 14 units of alcohol (1 unit= 360 ml beers/45 ml liquor containing 40% alcohol/150ml grape wine) 6 months prior to screening period, positive results of alcohol breath test and the volunteers who cannot give up drinking during study.
• •10. The participants who smoked daily \>5 sticks of cigarette 3 months prior to first dose or cannot give up smoking during study.
• •11. The participants who have blood donation or excessive bleeding(\>200ml) 3 months prior to first dose, and planned to donate blood or blood constituent.
• •12. The participants who were taking any prescription medicine、CYP3A4 inducers/inhibitors within 1 month prior to first dose; any OTC, health care products (including vitamins), traditional chinese medicine within 2 weeks prior to screening period.
• •13. The participants who participated other clinical trials and took the investigational drug 3 months prior to first dose.
• •14. The participants who have positive test result in HBsAg, Anti-HCV, Anti-HIV and TPPA.
• •15. Any condition affecting the drug taking, or affecting the oral absorption, include any kind of severe chronic gastroenteropathy, history of gastrointestinal resection or surgery, uncontrollable nausea or vomit, disability in swallowing.
• •16. The participants who have history of needlesickness and blood phobia, and those with severe bleeding tendency.
• •17. The participants who cannot comply with the roles of unified diet.
• •18. The participants who cannot tolerate blood collection through venipuncture.
• •19. The participants who have chronic overconsumption (\> 8 cup one day, 1 cup=250 ml) of tea, coffee, and the drink with caffeine; or intake food or drink consist of any caffeine (i.e., coffee, strong tea, and chocolate );
• •20. Any intake of drink or food, enriched in xanthine and grapefruit, that could affect the drug's absorption, distribution, metabolism and excretion.
• •21. Any factors judged by investigator that the participants cannot meet.