Lead Sponsor

Eli Lilly and Company

Age

15 - 80 years

Sex

ALL

Healthy Volunteers

No

•Diagnosis of CD for at least 3 months prior to baseline
•Confirmed diagnosis of moderate to severe CD as assessed by SF, AP score, and SES-CD
•Demonstrated intolerance, loss of response or inadequate response to conventional or to biologic therapy for CD
•If female, subject must meet the contraception recommendations

•Have a current diagnosis of ulcerative colitis, inflammatory bowel disease-unclassified (IBD-U) (formerly known as indeterminate colitis) or short bowel syndrome
•Currently have or are suspected to have an abscess. Recent cutaneous and perianal abscesses are not exclusionary if drained, adequately treated and resolved at least 3 weeks prior to baseline or 8 weeks prior to baseline for intra-abdominal abscesses, provided that there is no anticipated need for any further surgery
•Have a stoma, ileoanal pouch or ostomy
•Have had a bowel resection within 6 months, or any kind of intra-abdominal or extra abdominal surgery within 3 months of baseline
•Have ever received any monoclonal antibodies binding IL-23