Effects of Short-term Intensive Insulin Therapy on Long-term Complications in Type 2 Diabetes

Exclusion Criteria

• •1. Type 1 diabetes or special type of diabetes;
• •2. Acute complications of diabetes (including DKA, HHS and lactic acidosis) when diagnosed as diabetes;
• •3. Serious microvascular complications: proliferative stage of retinopathy; urine AER \>300 mg/g or urine protein positive, quantification \>0.5 g/d; uncontrolled painful diabetic neuropathy and significant diabetic autonomic neuropathy when diagnosed as diabetes;
• •4. Severe macrovascular complications: acute cerebrovascular accident, acute coronary syndrome, vascular intervention for peripheral arterial disease or amputation requiring hospitalization within 12 months prior to enrollment when diagnosed as diabetes;
• •5. Blood creatinine clearance less than 50 ml/min, alanine aminotransferase ≥2.5×upper limit of normal, total bilirubin ≥1.5×upper limit of normal; Hemoglobin \<100 g/L or need regular blood transfusion;
• •6. Use of drugs that may influence blood glucose within 12 weeks;
• •7. Systemic infection or serious concomitant disease; patients with malignancy or chronic diarrhea;
• •8. Uncontrolled endocrine gland dysfunction;
• •9. Patients with mental or communication disorders;
• •10. Chronic cardiac insufficiency, heart function class III and above;
• •11. Pregnant women, lactating women and women of child bearing age who are not willing to take contraception during the study;
• •12. Subjects who don't cooperate, cannot be followed up or have difficulty in completing the study considered by the investigator.