Evaluate the Infectivity Equivalence of Current and New Lots of Plasmodium Falciparum Strain NF54

Exclusion Criteria

• •You must not have any of the following:
• •* Any history of malaria infection or having been given a malaria vaccine
• •* Any history travel to a country with falciparum malaria in the past 6 months, or planned travel to such an area during the course of the study
• •* Any history of having lived in an area with falciparum malaria for more than 5 years.
• •* Any use of medications that prevent or treat malaria during the 1 month prior to challenge or planned use during the study (outside of the drugs provided by the study team).
• •* Any serious medical illness or condition involving the heart, liver, lungs, or kidneys
• •* Any significant risk for developing heart disease in the next 5 years. The risk for developing heart disease in the next 5 years will be determined by a combination of the following factors: high blood pressure, smoking, weight, family history of heart disease and the presence of diabetes
• •* Any medical illness or condition involving your blood or immune system (to include sickle cell trait or thalassemia trait)
• •* Any abnormal (as determined by a physician) screening laboratory test results
• •* Any history of neurologic disease (including migraines or seizures)
• •* Any history of psoriasis (itchy skin rash) or porphyria (rare disturbance of metabolism), since these conditions could get worse after treatment with chloroquine (a medication for treating malaria).
• •* You have had your spleen removed
• •* Any past or current infection with HIV, Hepatitis C, or Hepatitis B
• •* Any use of investigational drugs or vaccines within 1 month before starting the study
• •* Any allergy to or inability to take the anti-malaria medications used in this study
• •* Any history of allergic reaction to mosquito bites that required hospitalization
• •* You must not be pregnant or nursing, or have any plans to become pregnant or breastfeed during the period from now through 3 months after malaria challenge
• •* Any chronic use of steroids or other medications that affect the immune system in the 6 months before malaria challenge. Inhaled and topical (used on the skin) steroids are allowed.
• •* You plan to have surgery between enrollment and 3 months after malaria challenge.
• •* Any active alcohol or drug abuse
• •* You have any other physical or psychologic condition or laboratory abnormality that the study doctor thinks may increase your risk of having side effects or compromise the results of the study.