CHILD (Child Health and Infection With Low Density) Malaria

This is a 3-arm open-label randomized control trial of 600 children aged 6 months to 10 years in Tanzania, where transmission is low and a high proportion of infections are low-density. Standard of care based on passive case detection (PCD) using rapid diagnostic test (control arm) will be compared to two different approaches to detect and treat P. falciparum LMI: active case detection using molecular testing (ACDm) and PCD using molecular testing (PCDm). Aims are: 1. To assess the impact of standard PCD plus ACDm vs standard PCD on long-term child health 2. To assess the impact of PCDm vs standard PCD on long-term child health 3. To evaluate the cost-effectiveness of ACDm and PCDm