PENTHROX™ in the Canadian Emergency Department (ED)

Exclusion Criteria

• •1. Multi-level trauma
• •2. Women of child bearing potential who are pregnant or peri partum, including labour
• •3. An altered level of consciousness, due to any cause, including head injury, drugs, or alcohol
• •4. Clinically significant renal impairment
• •5. A history of liver dysfunction after previous MEOF use or other halogenated anesthetics
• •6. Hypersensitivity to MEOF or other halogenated anesthetics, or to butylated hydroxytoluene
• •7. Known or genetically susceptible to malignant hyperthermia or a history of severe adverse reactions in either patient or relatives
• •8. Exacerbation of an underlying condition (i.e., chronic pain)
• •9. Clinically evident or potential hemodynamic instability as per the opinion of the investigator
• •10. Clinically evident respiratory impairment as per the opinion of the investigator
• •11. Prior treatment with PENTHROX within 3 months