Brain Imaging Biomarkers of Pathological Brain Aging in Late-life Depression

Exclusion Criteria

• •history or evidence of psychiatric disease, as assessed by clinical interview (healthy controls only).
• •history of major other neurological disorder, or major internal pathology that may make him/her unfit for participation according to the interpretation by the investigator (including cardiac, lung, haematological, gastro-intestinal disorders or cancer);
• •current user (including ''recreational use'') of any illicit drugs,including cannabis, or has a history of drug or alcohol abuse;
• •had exposure to ionizing radiation (\> 1 mSv) in other research studies within the last 12 months;
• •has a contra-indication for MRI scanning;
• •suffers from claustrophobia or cannot tolerate confinement during PET-MRI scanning procedures; cannot lie still for 60 minutes inside the scanner;
• •does not understand the study procedures
• •unwilling or unable to perform all of the study procedures, or is considered unsuitable in any way by the principal investigator;
• •underwent ECT within the last 3 months before enrollment (patients)