Time Restricted Feeding on Impaired Glucose Regulation(TRIG Trial)

Exclusion Criteria

• •1. Confirmed diagnosis of DM or on hypoglycaemic treatment
• •2. Women who are pregnant or breast-feeding at recruitment
• •3. Patients taking glucocorticoid at recruitment
• •4. Active and uncontrolled thyroid diseases (including subjects on thyroid replacement therapy or anti-thyroid drugs) or active endocrine diseases such as Cushing's syndrome or Acromegaly at recruitment
• •5. Serious liver dysfunction or chronic kidney disease (AST or ALT \> 3 times the upper limit of normal, or eGFR\<30 ml/min/1.73 m2);
• •6. History of serious cardiovascular or cerebrovascular disease (angina, myocardial infarction or stroke) in the past 6 months;
• •7. Taking medications affecting weight or energy intake/energy expenditure in the last 6 months, including weight loss medications, antipsychotic drugs or other medications as determined by the study physician;
• •8. Currently participating in weight loss programs or weight change in the past 3 months (\> 5% current body weight) ;
• •9. Patients who cannot be followed for 24 months (due to a health situation or migration);
• •10. Patients who are unwilling or unable to give informed consent.