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Acute Exposure of High Altitude on Cardiac Output | Clinical Trials | Clareo Health

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COMPLETEDNANCT03637218

Acute Exposure of High Altitude on Cardiac Output

Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response High Altitude (Säntis; 2500m above sea level) on non-invasive cardiac output assessments by...

Lead sponsor: University of Zurich•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Zurich

Low altitude baseline measurements will be performed in Zurich (460m asl) including Echocardiography, Right heart catheterization, 6MWT, pulmonary function test, clinical assessment and blood gas Analysis. Randomly assigned to the order of testing, the participants will be tested in Low Altitude (Zurich, 470m) and at High Altitude (2500m). During the exposure High Altitude (2500m) and Low Altitude (Zurich; 470m) up to 5 hours, the participants cardiac output non-invasively assessed will be measured repetitive during the whole intervention.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Informed consent
•PH diagnosed according to internation Guidelines: mPAP ≥ 25 mmHg along with a PAWP ≤15 mmHg during right heart catheterization at the time of Initial diagnosis
•PH class 1 (PAH) or 4 (CTEPH)
•Stable condition, on the same medication for \> 4 weeks
•Patient live permanently at an altitude \< 1000m asl.

Exclusion Criteria

•Resting PaO2 ≤7.3 kPA corresponding to the requirement of long-term oxygen therapy \> 16hour daily (nocturnal oxygen therapy alone is allowed)
•Severe daytime hypercapnia (pCO2 \> 6.5 kPa)
•Susceptibility to high altitude related diseases (AMS, HAPE, etc.) based on previous experienced discomfort at altitudes.
•Exposure to an altitude \>1500m for ≥3 nights during the last 4 weeks before the study participation
•Residence \> 1000m above sea level
•Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, neurological or orthopedic problems with Walking disability
•Women who are pregnant or breast feeding

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: January 7, 2020Terms

Trial snapshot

StatusCOMPLETED

PhaseNA

Enrollment28

Start dateJul 2018

Last updatedJan 7, 2020

Condition

Pulmonary Hypertension

Locations shown

Respiratory Clinic, University Hospital of Zurich

Zurich

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 7, 2020Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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