Effect of Intranasal Insulin on Cognitive Processes and Appetite

Exclusion Criteria

• •Subjects who have a non-removable metal object in or at their body, such as, for example: Heart pace-maker, artificial heart valve, metal prosthesis, implants or splinters, non-removable dental braces
• •Tattoos, that are older than 15 years
• •Claustrophobia
• •Limited temperature perception and/or increased sensitivity to warming of the body
• •Pathological hearing ability or an increased sensitivity to loud noises
• •Lack of ability to give informed consent
• •Operation less than three months ago
• •Simultaneous participation in other studies that involve drugs intake or blood spending
• •Acute illness or infection during the last 4 weeks
• •Cardiovascular disorders (e.g., hypertrophic cardiomyopathy, long QT syndrome)
• •Moderate or severe head injury
• •Eating disorders
• •No metabolic (e.g. metabolic disorder, diabetes, insulin resistance), psychological (e.g. depression) or neurological (e.g. epilepsy, headache disorder, multiple sclerosis, traumatic brain injuries) diseases or medication in relation to these diseases.
• •Intake of any medication that can interfere with the drug or measurements.
• •Current weight loss regimens, or more then 5kg weight loss in the last 3 months
• •Smoking
• •Current pregnancy or breastfeeding
• •Current or past history of drug or alcohol dependency - alcohol consumption exceeding 12 units a week
• •Food allergies (e.g. peanut allergy lactose and gluten intolerance) or vegetarian/vegan diet
• •Disliking the study lunch