The Role of Estrogen in Adipocyte Remodeling Following Surgical Menopause

Exclusion Criteria

• •Unstable weight in the last 3 months \[gain or loss \>7 lb (or 3.2 kg)\]
• •Significant changes in diet or physical activity level within the past month
• •Smoking or use of tobacco products within the last 3 months
• •Amenorrhea (or absence of regular monthly cycles)
• •History of clinically diagnosed diabetes or a fasting blood glucose \>126 mg/dL
• •Average screening blood pressure \>140/90 mmHg
• •Chronic use of systemic glucocorticoids, systemic adrenergic-stimulating agents, antipsychotic/antidepressant medications, thiazolidinediones, and other medications that cause clinically significant weight gain, weight loss or are known to make changes in fat cell number/size.
• •Previous bariatric surgery (or other surgeries) for obesity or weight loss
• •Use of over the counter or prescription weight loss products
• •History of metabolic diseases (other than diabetes)
• •History of neurological disease
• •History of cardiovascular disease (or other chronic diseases)
• •Unable or unwilling to have an MRI performed
• •Pregnant, planning to become pregnant, or breastfeeding
• •Use of hormone replacement therapy.
• •Unwilling to discontinue any form or hormonal therapy (e.g., contraceptives including birth control pills, vaginal ring, injections, implant, or skin patch; hormonal supplements, etc.) upon enrollment (after the Screening Visit).