Short-term Fat Overfeeding on the Effects of Liver Metabolism

Exclusion Criteria

• •The participant is unwilling or unable to give informed consent for participation in the study. - Aged ≤18 or ≥65 years
• •Body Mass Index ≤19 or ≥35kg/m2
• •Blood haemoglobin \<135mg/dL for men and \<120mg/dL for women
• •Donated (or lost) ≥250 ml of blood in the previous two months.
• •On a weight loss diet or have decreased their body weight by \>5% in the previous 3 months.
• •Have increased their body weight by \>5% in the previous 3 months.
• •Any metabolic condition or relevant drug therapy
• •Current smoker
• •History of alcoholism or a greater than recommended alcohol intake (\>30 g of alcohol daily for men and \>20 g of alcohol daily for women)
• •Haemorrhagic disorders
• •Anticoagulant treatment
• •History of albumin allergy
• •Pregnant or nursing mothers
• •Women prescribed any contraceptive agent or device including oral contraceptives, hormone replacement therapy (HRT) or who have used these within the last 12 months History of severe claustrophobia
• •Presence of metallic implants, pacemakers, or are unwilling to remove any piercings
• •History of an eating disorder or any other psychological condition that may affect the participant's ability to adhere to study intervention/experimental diets.