Effect of Mental Imagery Training on Brain Plasticity and Motor Function in Individuals With Parkinson's Disease

Exclusion Criteria

• •Age \< 40 years
• •Non-English speaking
• •Pregnancy
• •Breastfeeding
• •Excessive alcohol consumption (\> 7 drinks per week for women, \> 14 drinks per week for men) or substance use
• •History of a neurological disorder such as a brain tumor, stroke, central nervous system infection, multiple sclerosis, movement disorder (other than PD), or seizures
• •History of schizophrenia, bipolar disorder, attention deficit disorder, or obsessive compulsive disorder
• •History of head injury with loss of consciousness
• •Metallic surgical implants or traumatically implanted metallic foreign bodies
• •Inability to lie flat for about an hour
• •Discomfort being in small, enclosed spaces
• •Dementia (Montreal Cognitive Assessment score \< 21)
• •Depression (Beck Depression Inventory-II score \> 19)
• •Hoehn \& Yahr stage \> 3 (i.e., able to stand and walk, but not fully independent)
• •Focal neurological findings on exam that suggest cerebral pathology other than that associated with parkinsonism
• •Motor symptoms that could potentially introduce too much motion artifact in the imaging data (e.g., MDS-UPDRS resting tremor score \> 1 in limbs, head/chin tremor, or dyskinesia by history or exam).