Manganese-Enhanced Magnetic Resonance Imaging of the Myocardium

Inclusion Criteria

• •All subjects to be entered must:
• •≥ 18 years of age
• •if female, be non-pregnant as evidenced by a urine pregnancy test or post-menopausal or surgically sterile
• •provide written informed consent after having received oral and written information about the study
• •Healthy Volunteers
• •Healthy adult with no known pre-existing medical conditions
• •Ischaemic Cardiomyopathy
• •Ischaemic cardiomyopathy as diagnosed by reduced LV ejection fraction (≤40%) secondary to one or more ischaemic events
• •Angiographically demonstrated LMS, LAD disease, or ≥2 vessel disease
• •NHYA class I-III heart failure, with stable symptoms not requiring change to diuretic therapy in the preceding month
• •Dilated Cardiomyopathy
• •Dilated cardiomyopathy characterised with echocardiography by reduced left ventricular systolic function with impaired systolic function (ejection fraction \<40%).
• •NHYA class I-III heart failure, with stable symptoms not requiring change to diuretic therapy in the preceding month
• •Hypertrophic Cardiomyopathy
• •Established diagnosis of hypertrophic cardiomyopathy
• •Left ventricular wall thickness ≥15mm in any segment
• •Repolarisation abnormalities on 12-lead electrocardiogram NHYA class I-III heart failure, with stable symptoms not requiring change to diuretic therapy in the preceding month