Correction of Neonatal Glutathione by N-acetylcysteine in Pregnant Women at Risk of Premature Birth (GSH MAP)

Exclusion Criteria

• •Age \< 18 years old
• •Major under trusteeship or curatorship
• •Maternal refusal and / or Incapacity to understand the benefits and potential risks of the protocol and to sign an informed consent form.
• •A sonographic cervix ≥ 20 mm
• •Mothers WITH:
• •* A Body mass index less than 18 kg/m2 and greater than 40 kg/m2 before pregnancy
• •* Type I, II diabetes
• •* Epileptic disorders
• •* A history of asthma
• •* A hemorrhagic pathology
• •* Maternal infection (HIV, hepatitis B and C) other than chorioamnionitis
• •Patients in labour treated with magnesium sulphate
• •Multiple pregnancy
• •A known allergy/ hypersensitivity to N-acetylcysteine
• •Fetal pathology other than intrauterine growth retardation (such as: karyotype abnormality, malformation, intrauterine growth retardation \<10th percentile)
• •Current high doses of antioxidants treatments (vitamin supplements, ...)
• •Patient with proven pre-eclampsia
• •Patient with heart failure
• •Patient with nephropathy
• •Patient with medically known lactose intolerance
• •Patient not affiliated with an appropriate social security system