Synbiotics in Patients at RIsk fOr Preterm Birth

Inclusion Criteria

• •1. Signed written informed consent must be obtained before any study assessment is performed;
• •2. 18 years of age or older;
• •3. Singleton pregnancy;
• •4. Pregnancy consultation between 8 and 10 weeks gestation.
• •5. At least one of the following risk factors for spontaneous preterm birth:
• •* Prior spontaneous preterm birth, defined as delivery between 24 and 36 weeks following PPROM, preterm labor or cervical insufficiency
• •* PPROM ≤36 weeks in previous pregnancy
• •* Prior spontaneous second-trimester pregnancy loss, defined as PPROM, preterm labor or cervical insufficiency with birth between 14 and 24 weeks.