Clinical Trial to Evaluate the Safety and Effects of Ethnicity and Food on Pharmacokinetics of YH25448

Exclusion Criteria

• •1. Clinically significant chronic infection (e.g. AIDS) or clinically significant medical or psychiatric illness
• •2. Hypotension (SBP ≤ 90 mmHg or DBP ≤ 50 mmHg) or hypertension (SBP ≥ 150 mmHg or DBP ≥ 100 mmHg)
• •3. A marked baseline prolongation of QTc greater than 450 msec by Bazett's formula
• •4. Within 14 days prior to the first administration of investigational product, use of prescription drugs or herbal medication, or within 7 days use of any over-the-counter medications